Publications on Prevotella copri from the Barwon Infant Study
Maternal carriage of Prevotella during pregnancy associates with protection against food allergy in the offspring. Vuillermin PJ, O’Hely M, Collier F, Allen KJ, Tang MLK, Harrison LC, Carlin JB, Saffery R, Ranganathan S, Sly PD, Gray L, Molloy J, Pezic A, Conlon M, Topping D, Nelson K, Mackay CR, Macia L, Koplin J, Dawson SL, Moreno-Betancur M, Ponsonby AL; J. Craig Venter Institute; BIS Investigator Group. Nat Commun. 2020 Mar 24;11(1):1452.
- In this landmark publication data from mother-child pairs (n=58 infants that developed food allergy, and n=258 controls) found that maternal carriage of P. copri during pregnancy was associated with protection against food allergy in the offspring at 1 year of age.
Maternal carriage of the gut bacterium Prevotella copri during pregnancy is associated with reduced offspring atopy at 4 years. Gray LEK, Collier F, O’Hely M, Sly PD, Ranganathan S, Vuillermin PJ, BIS Investigator Group. Poster presentation, Barwon Health-Deakin University Research Symposium, July 2020.
- This poster presents the most recent data in which P. copri was measured by PCR in the gut microbiome of 929 women during pregnancy. The presence of P. copri in the mothers gut protected the infants from later atopic wheeze or asthma in offspring at 4 years of age, and a higher abundance of P. copri was specifically associated with protection from aeroallergen sensitisation.
Gut microbiota composition during infancy and subsequent behavioural outcomes. Loughman A, Ponsonby AL, O’Hely M, Symeonides C, Collier F, Tang MLK, Carlin J, Ranganathan S, Allen K, Pezic A, Saffery R, Jacka F, Harrison LC, Sly PD, Vuillermin P; BIS Investigator Group. EBioMedicine. 2020 Feb;52:102640.
- In an unselected cohort of 201 children, there was a clear association between decreased abundance of Prevotella in faecal samples collected at 1 year of age and increased behavioural problems at 2 years.
Rapid PCR identification of Prevotella copri in an Australian cohort of pregnant women. Gray L, Hasebe K, O’Hely M, Ponsonby AL, Vuillermin P, Collier F; BIS Investigator Group. J Dev Orig Health Dis. 2020 Jun;11(3):228-234.
- This paper describes a method developed to allow rapid and sensitive detection of P. copri in any bacterial sample.
Cohort Profile: The Barwon Infant Study. Vuillermin P, Saffery R, Allen KJ, Carlin JB, Tang ML, Ranganathan S, Burgner D, Dwyer T, Collier F, Jachno K, Sly P, Symeonides C, McCloskey K, Molloy J, Forrester M, Ponsonby AL. Int J Epidemiol. 2015 Aug;44(4):1148-60.